Yibo Yuan1,
Lin Liu1 
,
Shuqin Feng2,
Youtian Ma3,
Qingben Wang1
For correspondence:- Lin Liu Email: Liulin741@163.com Tel:+8615153649983
Accepted: 21 September 2018 Published: 31 October 2018
Citation: Yuan Y, Liu L, Feng S, Ma Y, Wang Q. Effects of different remifentanil doses on the stress reaction and BIS value of video laryngoscope-guided tracheal intubation. Trop J Pharm Res 2018; 17(10):2025-2030 doi: 10.4314/tjpr.v17i10.19
© 2018 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..
Purpose: To explore the affinity of different remifentanil doses for intravenous anesthesia in video laryngoscope-guided tracheal intubation.
Methods: Eighty patients who required anesthesia for elective non-ophthalmic surgery were included. They were divided into four groups (A, B, C and D) and received a different dose of either 1, 1.5, or 2 μg/kg remifentanil or a dose of 2 μg/kg fentanyl, respectively. An anesthetic state was achieved and maintained by administration of 3 - 5 mg/kg propofolum and 0.1 - 0.3 mg/kg remifentanil. The mean value of the various indices, including arterial pressure (MAP), bispectral index and heart rate (HR) were recorded prior to anesthesia induction (T0), prior to intubation (T1), instantly before intubation (T2), and at 1 (T3), 3 (T4) and 5 (T5) after the intubation. Cortisol concentration was measured at T0, T1 and T5.
Results: Remifentanil (1 μg/kg) induced a moderate increase in HR and MAP at T3 compared with fentanyl. HR and MAP in the lower dose group were significantly higher than those in groups B and C at T3. Compared to T1, the concentrations of cortisol decreased after anesthesia and then significantly increased during tracheal intubation. Cortisol concentration in group B was the lowest at T5.
Conclusion: The most effective concentrations of remifentanil are 1 and 1.5 μg/kg for anesthesia induction and tracheal intubation, respectively.
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